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64GB DDR5 Server RAM – 4800MHz & 5600MHz HPE SmartMemory
Unlock maximum memory density and bandwidth in your HPE ProLiant Gen11 server with the 64GB DDR5 ECC Registered SmartMemory — available in two speed grades: DDR5-4800 and DDR5-5600. With 64GB per DIMM, these high-density modules are built for the most demanding enterprise environments — large-scale virtualisation, in-memory databases, AI inferencing, big data analytics, and SAP HANA — delivering double the per-DIMM capacity of the 32GB variant while maintaining full HPE qualification and compatibility.
Both modules are HPE SmartMemory — rigorously tested and certified on HPE Gen11 platforms to unlock exclusive RAS features, Active Health System memory monitoring, and top-rated operational speeds unavailable with generic JEDEC memory.
Quick Comparison — 4800MHz vs 5600MHz
| Specification | DDR5-4800 (4800MHz) | DDR5-5600 (5600MHz) |
|---|---|---|
| HPE Option Part Number | P50312-B21 | P64707-B21 |
| HPE Spare Part Number | P56153-001 | P65255-001 |
| HPE Assembly Part Number | P43333-1A1 | P53627-0A1 |
| Alternate Part Number | P50312-H21 | — |
| Capacity | 64GB (1× 64GB) | 64GB (1× 64GB) |
| Memory Standard | DDR5-4800 / PC5-38400 | DDR5-5600 / PC5-44800 |
| Speed | 4800 MT/s | 5600 MT/s |
| CAS Latency | CL42 (42-42-42) | CL46 (46-45-45) |
| Rank / Width | Dual Rank × 4 (2Rx4) | Dual Rank × 4 (2Rx4) |
| DIMM Type | EC8 RDIMM — 288-pin | EC8 RDIMM — 288-pin |
| Operating Voltage | 1.10V | 1.10V |
| ECC | Yes | Yes |
| Peak Bandwidth | ~38,400 MB/s | ~44,800 MB/s |
| Compatible Servers | HPE Gen11 Intel (4th & 5th Gen Xeon) | HPE Gen11 Intel (5th Gen Xeon required for full speed) |
💡 The DDR5-5600 module requires a 5th Generation Intel Xeon Scalable processor (Emerald Rapids) to operate at its full 5600 MT/s rated speed. In Gen11 servers with 4th Gen Intel Xeon (Sapphire Rapids), the 5600MHz DIMM will automatically downclock to 4800 MT/s. If maximum compatibility across all Gen11 platforms is required, choose the DDR5-4800 variant.
Product 1 — HPE 64GB DDR5-4800 Registered Smart Memory Kit (P50312-B21)
The broadest-compatibility 64GB DDR5 SmartMemory module for HPE Gen11. Engineered as a Dual Rank × 4 RDIMM, it balances high capacity with excellent signal integrity across all HPE Gen11 Intel-based server platforms — including both 4th and 5th Generation Intel Xeon Scalable processors. Ideal for organisations deploying high-density memory configurations without needing the absolute top speed tier.
| Specification | Details |
|---|---|
| Part Number (Option) | P50312-B21 |
| Part Number (Spare) | P56153-001 |
| Part Number (Assembly) | P43333-1A1 |
| Alternate Part Number | P50312-H21 |
| Capacity | 64GB (1× 64GB) |
| Memory Technology | DDR5 SDRAM |
| Memory Standard | DDR5-4800 / PC5-38400 |
| Speed | 4800 MT/s |
| CAS Latency | CL42 (42-42-42) |
| Rank Configuration | Dual Rank × 4 (2Rx4) |
| DIMM Type | EC8 Registered DIMM (RDIMM) |
| Pin Count | 288-pin |
| Operating Voltage | 1.10V |
| Error Correction | ECC (Error Correcting Code) |
| Peak Bandwidth | ~38,400 MB/s (PC5-38400) |
| Operating Temperature | 0°C to 85°C |
| Dimensions | 133.35mm × 30.73mm × 3.10mm |
| Warranty | 3 Years (HPE Limited Warranty) |
Compatible HPE Servers — DDR5-4800 (P50312-B21)
| Server Family | Compatible Models |
|---|---|
| HPE ProLiant DL Gen11 | DL20 Gen11, DL320 Gen11, DL360 Gen11, DL380 Gen11, DL380a Gen11, DL560 Gen11, DL580 Gen11 |
| HPE ProLiant ML Gen11 | ML30 Gen11, ML110 Gen11, ML350 Gen11 |
| HPE ProLiant BL Gen11 | BL460c Gen11 |
| HPE Synergy Gen11 | 480 Gen11 Compute Module |
| HPE Apollo Gen11 | Apollo Family Gen11 (AMD & Intel platforms) |
⚠️ DIMM availability for specific platforms is subject to completion of HPE certification testing. Always verify compatibility using the HPE Memory Configurator or the relevant server’s QuickSpecs prior to purchase.
Product 2 — HPE 64GB DDR5-5600 Registered Smart Memory Kit (P64707-B21)
The high-performance 64GB DDR5 SmartMemory module, purpose-built for HPE Gen11 servers running 5th Generation Intel Xeon Scalable processors (Emerald Rapids). Operating at 5600 MT/s, this module delivers higher throughput and improved data access speeds compared to the 4800MHz variant — critical for workloads that are highly memory-bandwidth sensitive, such as in-memory analytics, large-scale virtualisation, and AI/ML inference engines.
| Specification | Details |
|---|---|
| Part Number (Option) | P64707-B21 |
| Part Number (Spare) | P65255-001 |
| Part Number (Assembly) | P53627-0A1 |
| Capacity | 64GB (1× 64GB) |
| Memory Technology | DDR5 SDRAM |
| Memory Standard | DDR5-5600 / PC5-44800 |
| Speed | 5600 MT/s |
| CAS Latency | CL46 (46-45-45) |
| Rank Configuration | Dual Rank × 4 (2Rx4) |
| DIMM Type | EC8 Registered DIMM (RDIMM) |
| Pin Count | 288-pin |
| Operating Voltage | 1.10V |
| Error Correction | ECC (Error Correcting Code) |
| Peak Bandwidth | ~44,800 MB/s (PC5-44800) |
| Operating Temperature | 0°C to 85°C |
| Dimensions | 133.35mm × 30.73mm × 3.10mm |
| Warranty | 3 Years (HPE Limited Warranty) |
Compatible HPE Servers — DDR5-5600 (P64707-B21)
| Server Family | Compatible Models (5th Gen Intel CPU Required) |
|---|---|
| HPE ProLiant DL Gen11 | DL320 Gen11, DL360 Gen11, DL380 Gen11, DL380a Gen11 |
| HPE ProLiant ML Gen11 | ML350 Gen11 |
| HPE ProLiant BL Gen11 | BL460c Gen11 |
| HPE Synergy Gen11 | 480 Gen11 Compute Module |
⚠️ Full DDR5-5600 speed is only achievable with 5th Generation Intel Xeon Scalable processors. On Gen11 servers with 4th Gen Intel Xeon (Sapphire Rapids), this module will operate at DDR5-4800. This module is NOT compatible with HPE Gen10 or earlier server generations.
DDR5 vs DDR4 — Performance Comparison
| Feature | DDR4-3200 (Previous Gen) | DDR5-4800 | DDR5-5600 |
|---|---|---|---|
| Max Speed | 3200 MT/s | 4800 MT/s | 5600 MT/s |
| Peak Bandwidth (per DIMM) | ~25,600 MB/s | ~38,400 MB/s | ~44,800 MB/s |
| Bandwidth Gain vs DDR4 | — | +50% | +75% |
| Operating Voltage | 1.20V | 1.10V | 1.10V |
| Sub-Channels per DIMM | 1 | 2 | 2 |
| On-Die ECC (ODECC) | No | Yes | Yes |
| Integrated PMIC | No | Yes | Yes |
| Burst Length | 8 | 16 | 16 |
| Max RDIMM Density (64GB) | Not available (max 32GB RDIMM) | 64GB per DIMM | 64GB per DIMM |
HPE SmartMemory — Key Features & Benefits
High Density & Scalability
- 64GB per DIMM enables massive memory density — up to 6.0TB total RAM in a fully populated HPE DL580 Gen11 (96 DIMM slots)
- Dual Rank × 4 architecture provides superior signal integrity at high density compared to × 8 configurations
- Scales efficiently from entry 1-DIMM configs up to fully populated high-density enterprise builds
- Ideal for reducing the number of DIMMs required to reach a target memory capacity (e.g. 512GB with 8 × 64GB vs 16 × 32GB)
High Performance
- DDR5 dual sub-channel architecture doubles effective memory bus width per DIMM slot
- Up to 75% more bandwidth per DIMM compared to DDR4-3200 (DDR5-5600 variant)
- Reduced memory access latency under sustained high-throughput workloads
- Higher burst length (16 vs 8) improves sequential data throughput for database and analytics workloads
High Reliability & Data Integrity
- ECC (Error Correcting Code) — detects and corrects single-bit memory errors in real time, preventing data corruption
- On-Die ECC (ODECC) — built into DDR5 DRAM silicon for additional error detection at the chip level before errors propagate
- Registered (RDIMM) design buffers address and command signals, significantly improving signal integrity in high-density configurations
- HPE qualification testing goes beyond JEDEC standards, ensuring stable performance under sustained 24/7 enterprise workloads
- Advanced memory error detection prevents unnecessary DIMM replacement and reduces unplanned downtime
Energy Efficiency
- Operating voltage reduced to 1.10V (from 1.20V in DDR4) — lower per-DIMM power consumption
- Integrated Power Management IC (PMIC) on each DDR5 module delivers more precise, per-DIMM voltage regulation
- In fully populated 24-DIMM servers, per-DIMM power savings across all slots compound into measurable reductions in total server power draw
HPE SmartMemory Exclusive Benefits
- Unlocks advanced HPE RAS features — Advanced ECC, Online Spare Memory, Mirroring — unavailable with standard JEDEC DIMMs
- Integrated with HPE Active Health System (AHS) for continuous memory health monitoring and predictive failure alerts via iLO
- Compatible with HPE Workload Profiles for automatic memory sub-system tuning to match workload type
- Monitored and managed via HPE iLO Amplifier Pack for fleet-wide memory visibility across hundreds of servers
- Only HPE SmartMemory is guaranteed to operate at top rated speeds on HPE Gen11 platforms
Sample High-Density Memory Configurations
| Server | DIMM Slots | Config (64GB DIMMs) | Total RAM |
|---|---|---|---|
| HPE DL360 Gen11 | 16 | 16× 64GB | 1.0 TB |
| HPE DL380 Gen11 | 32 | 32× 64GB | 2.0 TB |
| HPE ML350 Gen11 | 24 | 24× 64GB | 1.5 TB |
| HPE DL560 Gen11 | 64 | 64× 64GB | 4.0 TB |
| HPE DL580 Gen11 | 96 | 96× 64GB | 6.0 TB |
💡 Using 64GB DIMMs vs 32GB DIMMs halves the number of modules required to reach a given memory target — reducing total power consumption, simplifying inventory management, and leaving empty slots available for future capacity expansion.
Memory Population & Configuration Rules
- Always populate DIMMs in balanced, matched pairs per memory channel for maximum bandwidth and stability
- Do NOT mix DDR5 RDIMM (Registered) and DDR5 UDIMM (Unbuffered) types in the same server
- Do NOT mix DDR4 and DDR5 modules — they use different sockets and are electrically incompatible
- Do NOT mix DDR5 RDIMM and DDR5 LRDIMM (Load-Reduced) in the same server
- If mixing DDR5-4800 and DDR5-5600 DIMMs in the same server, all DIMMs will run at the lower speed (4800 MT/s)
- Maximum operational memory speed is always governed by the installed processor — a faster DIMM will not exceed the CPU’s supported memory speed
- For optimal performance, use HPE SmartMemory modules throughout — do not mix HPE SmartMemory with third-party standard DIMMs in the same server
- Use the HPE Memory Configurator at hpe.com/info/HPESC to validate population rules for your specific server and processor combination
Ideal Use Cases
- Large-scale server virtualisation — VMware vSphere, Microsoft Hyper-V, Red Hat KVM
- In-memory databases — SAP HANA, Redis, VoltDB, MemSQL
- Enterprise RDBMS — Oracle Database, Microsoft SQL Server, PostgreSQL
- AI and machine learning inference — large model serving requiring high-bandwidth memory
- High-performance private and hybrid cloud infrastructure
- Big data analytics and real-time streaming workloads
- ERP platforms — SAP, Microsoft Dynamics
- High-density VDI (Virtual Desktop Infrastructure) deployments
- Mission-critical 24/7 applications requiring maximum uptime and data integrity
What’s in the Box
- 1× 64GB DDR5 ECC Registered SmartMemory DIMM (as selected — 4800MHz or 5600MHz)
- HPE 3-Year Limited Warranty
For full compatibility information, memory population rules, and platform-specific guidance, refer to the official HPE DDR5 SmartMemory QuickSpecs and the HPE Memory Configurator at hpe.com/info/HPESC. All trademarks are the property of their respective owners.
By: Tony Kavoi
